The 1978 Wilkes 400 was held on October 1 at North Wilkesboro Speedway in North Carolina. The 0.625-mile short track hosted the 400-lap (250-mile) NASCAR Winston Cup event with a 27-car field and an attendance of 20,000.
Darrell Waltrip won the pole in his No. 88 DiGard Chevrolet with a qualifying speed of 109.397 mph. Waltrip led the first 381 laps, but Cale Yarborough, in the No. 11 Junior Johnson Chevrolet, mounted a remarkable comeback. Yarborough had fallen three laps down earlier due to handling issues, but chassis adjustments turned his car around.
Yarborough passed Waltrip and won by 14 seconds, earning $14,000 for his ninth victory of the season. The race saw only one caution for four laps and finished at an average speed of 97.847 mph. Bobby Allison finished third, Richard Petty fourth, and Neil Bonnett fifth.












